Home > Faculty > Dr. Jie Li

Jie Li, M.D., Ph.D. Dermatology and Cutaneous Surgery Cell Biology and Anatomy 1600 NW 10th Ave., RMSB Rm 2049A Telephone: (305)243-3365 Fax: (305)243-6191 Email: jli@med.miami.edu http://dermatology.med.miami.edu/

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Curriculum Vitae

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Research Interests

Laminins are major components of the extracellular matrix (ECM) in the basement membrane zone (BMZ) and influence a variety of important biological processes including cell attachment, migration, angiogenesis, wound healing and tissue development. The importance of laminins is best illustrated by human severe blistering disease, epidermolysis bullosa, due to the deficiency of laminin 5 and subsequent failure of wound repair. Our laboratory uses advanced cellular, molecular biology techniques and animal models to study the functions of two newly identified laminins, 8 (a4b1g1) and 10 (a5b1g1), in epithelial biological processes, including angiogenesis, wound healing and tumor invasion. Our current on-going researches involve following studies:

1. The role of laminins 8 and 10 in the integrin signaling in skin epidermal keratinocytes, dermal fibroblasts and blood vessel endothelial cells.
2. The functions of ECM and growth factors in regulating cell attachment, migration, terminal differentiation, epithelial homeostasis and wound repair.
3. The role of ECM and growth factors in regulating ECM deposition, dermal fibrosis and wound healing.
4. Epithelial tissue engineering and wound repair.
5. Microvascular endothelial cell biology, wound angiogenesis and tumor angiogenesis.
6. The correlation of laminin 10 expression with the progress and metastasis of malignant skin tumors of basal cell carcinoma, squamous cell carcinoma and melanoma.
7. Gene regulation in hair follicle development.

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Selected Publications

Askew DS, Li J, Ihle JN. Retroviral insertions in the murine His-1 locus activate the expression of a novel RNA that lacks an extensive open reading frame. Mol Cell Biol 14: 1743-51, 1994.

Brissette JL, Li J, Kamimura J, Lee D, Dotto GP. The product of the mouse nude locus, whn, regulates the balance between epithelial cell growth and differentiation. Genes & Development 10:2212-2221, 1996.

Li J, Witte D, Van Dyke T, Askew DS. Expression of the putative proto-oncogene His-1 in normal and neoplastic tissues. American J Pathology 150(4): 1297-1305, 1997.

Li J, Rhodes JC and Askew DS. Evolutionary conservation of putative functional domains in the human homolog of the murine His-1 gene. Gene 184:169-176, 1997.

St-Jacques B, Dassule HR, Karavanova I, Botchkarev VA, Li J, Danielian P, McMahon JA, Lewis PM, Paus R, McMahon AP. Sonic hedgehog signaling is essential for hair development. Current Biology, 8: 1058-1068, 1998.

Li J, Foitzik K, Calautti E, Baden HP, Doetschman T and Dotto PG. TGF-beta3 protects against TPA-induced keratinocyte cell death in vitro and in vivo. J Biol Chem 274:4213-4219, 1999.

Li J, Zhao B. Molecular biological basis of the skin. In: Clinical Dermatology, 3rd ed. (Zhao Bian, Ed). Jiangsu Scientific Press (China), pp68-92, 2001.

Li J, Zhang YP and Kirsner RS. Angiogenesis in wound repair: Angiogenic growth factors and the extracellular matrix. Microscopy Research and Technique. Accepted.

Li J, Zhou L, Tran HT, Chen Y, Nguyen N, Karasek MA and Marinkovich MP. Laminin 8 promotes angiogenesis related functions in microvascular endothelial cells through interaction with both b1 and aVb3 containing integrins. Submitted.

Li J, Tran HH, Chui C, Koch M and Marinkovich MP. The roles of laminin a5 chain in the development of normal human skin and hair follicle. Submitted.

View published research articles by Dr. Li in the National Library of Medicine

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