Toppel Family Professor of Pediatric Hematology-Oncology Pediatric Oncology, Bone arrow and stem cell transplantation, Childhood brain and spinal tumors, Pediatric sickle cell disease.

We have two major projects in our laboratory. The first project involves the discovery earlier this year of the disease gene for a rare infantile neurodegenerative disorder, X-linked spinal muscular atrophy. The second project focuses on the genetic basis of breast cancer in women of African ancestry.

Neuroproteomics, posttranslational modification of deimination, local protein synthesis in neuronal dendrites

"Computer-aided drug design, small molecule modulators of the costimulatory protein-protein interaction, immunomodulation for islet transplantation"

Molecular mechanisms of Tumorigenesis. Notch Signaling, mouse models of tumorigenesis. Cancer stem cells and pathway cross talk.

Our research program focuses on mechanisms of immune tolerance and its application to type 1 diabetes and islet transplantations.

Mechanisms underlying the etiology of ER-negative vs ER-positive breast cancer and studies aimed at re-expressing ER in ER-negative tumors leading to clinical trials.

Dr. Gilbert's research focuses on applications of genome technology to human genetics and the molecular genetics of autism, Alzheimer disease, Essential Tremor, and infectious disease such as tuberculosis. As a molecular biologist, his expertise is in gene analysis and characterization, positional cloning, mutation analysis, and animal models of human disorders.

Cardiac cell regeneration

Cell and molecular biology of bone; cell and molecular biology of aging; stem cells and reparative medicine

"The Cardiac Signal Transduction and Cellular Biology Laboratory at the University of Miami Miller School of Medicine is committed to the elucidation of the signal transduction pathways of the cardiac myocyte. In particular, we are interested in the role that multimolecular signaling complexes play is the regulation of myocyte function."

Immunology of islet transplantation in pre-clinical models and in clinical subjects; immunology of clinical type 1 diabetes.

Molecular control and manipulation of cell surface receptor signaling with a focus on ERBB2 and ERBB3 receptors. Special emphasis is placed on the role of the macromolecular context in which signaling occurs, its organizing principles and consequences of and opportunities for perturbation.

Our laboratory uses advanced cell and molecular biology techniques and animal models to study skin related problems. We are specially interested in the function and mechanicsms involved in the epithelial extracellular matrix.

molecular mechanisms of control of breast cancer growth and malignant behavior

We are studying pathogenesis of lymphoma and biological processes in normal B cells

"Molecular, cellular and genetic mechanisms of viral carcinogenesis of Kaposi sarcoma. Activation of tumor angiogenesis and genetic instability by the Kaposi sarcoma herpesvirus/ KSHV."

My research is focused on beta-cell function and responses to inflammation in the context of pancreatic islet transplantation and type 1 diabetes development.

Understanding the molecular pathways that regulate how HER-2 signals cell growth.Development of novel therapeutics and other novel antibody and chemotherapy combination therapies for breast cancer

Modulation of cellular redox status to enhance activation of tumor suppressor pathways in cancer cells

"Research focuses on innate host defenses of the airways including mucociliary clearance, mucus secretion, ciliary beating and lactoperoxidase system and recovery from insults."

Dr. Singal’s research focuses on the epigenetic mechanisms that inactivate certain tumor-suppressor genes in prostate cancer and designing clinical trials based on lab research.

"My research interests pertain to the role of the innate immune system, particularly of macrophages/monocytes, in the immune suppression observed in mice bearing advanced tumors. Peritoneal and tumor-associated macrophages and their precursors, monocytes in the circulation, represent and exhibit different levels of local and systemic immune suppression in the host. We have found that transcripition factors NFkB, STAT1 and STAT3 are differentially expressed in these cells, resulting in altered cell signaling pathways and cytokine gene expression patterns."

Dr. Vance's primary areas of expertise are in Neurogenetics, especially in Parkinson disease and Charcot-Marie-Tooth Disease, and also in cardiovascular genetics, human genotyping and banking of DNA samples, and the molecular aspects of the positional cloning of human disease. His research has focused on the application of clinical, molecular, and mathematical genetic techniques to identify genes leading to human disease.

Retinal cell biology; photoreceptor degeneration; retinal vascular disorders