The primary focus of my laboratory is the neuroimunological basis of disease or injury to the central nervous system. To achieve this goal we focus primarily on the role of astrocytes in health and disease and how modulating the activation of the NF-kB family of transcription factors alters neuroimmune responses.

Research in the lab is focused on axon growth and guidance during development and regeneration

Molecular mechanisms of Tumorigenesis. Notch Signaling, mouse models of tumorigenesis. Cancer stem cells and pathway cross talk.

Our research program focuses on mechanisms of immune tolerance and its application to type 1 diabetes and islet transplantations.

"We study survival and regeneration in the developing and adult nervous system, bridging molecular, cellular, and in vivo approaches. Additional projects focus on the use of stem cells and nanotechnology."

Cardiac cell regeneration

"The research in the laboratory focuses on the study of: (1) molecular pathways that regulate self-renewal, activation and differentiation of hematopoietic stem cells and progenitors, (2) molecular pathways supporting self-renewal and differentiation of cancer stem cells, and (3) stem cell transformation and leukemogenesis."

"My research focuses on the initiation of inflammation, autophagy and apoptosis in the CNS after traumatic brain and spinal cord injury."

We are interested in understanding how T lymphocytes: a) control the process of hematopoietic progenitor cell engraftment following marrow / blood transplantation and b) mediate anti-tumor immunity against malignancies in individuals post-transplant.

The primary focus of our research is the use of cellular therapies to repair diseased tissues and organs. We are exploring conditions for in vitro generation of cellular products for use in patients.

Our laboratory is exploring the potential for cell transplantation and/or gene therapy to alleviate chronic pain.

"Novel mechanisms of signal transduction, with a focus on heterotrimeric G proteins and Ca2+ binding proteins. Structure-function aspects and subcellular localization of signaling proteins"

"Our areas of research center on the development of the nervous system, neurotrophin signaling in neural cells and repair of the CNS after spinal cord injury. For the development of nervous system we try to understand how mitogenic factors influence cell numbers and how cell fates are linked to specific transcriptional networks. We use live fluorescent imaging techniques to study neurotrophin signaling. For spinal cord injury repair strategies, we utilize modified neurotrophins and grafting of CNS derived cells. We integrate several approaches including Cell Biology, Molecular Biology, Biochemistry, Genetics and Imaging techniques."