Education
Fu-Jen Catholic University, Taipei, Taiwan
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B.S.
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1981
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Biology |
University of Louisiana at Monroe, Monroe, LA
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M.S. |
1983 |
Biology |
UMDNJ-New Jersey Medical School, Newark, NJ
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Ph.D. |
1988 |
Biochem. & Mol. Biology |
Georgetown U. Medical School, Washington, DC.
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M.S. |
1997 |
Biostatistics & Epidemiology |
Professional Positions
| 1981-1983 |
Graduate Teaching Assistant, The University of Louisiana at Monroe, Monroe, LA. |
| 1983-1988 |
Graduate Teaching Assistant, UMDNJ-New Jersey Medical School, Newark, NJ. |
| 1988-1990 |
Postdoctoral Associate, Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers University, Piscataway, NJ. |
| 1990-1994 |
Molecular Epidemiology Lab Director, Cancer Prevention Research Institute, New York, NY. |
| 1994-1998 |
Assistant Professor, Department of Pharmacology, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC. |
| 1998-2004 |
Assistant Professor, Associate Professor (2002); tenured (2004), Departments of Cancer Biology, Public Health Sciences and Radiation Oncology, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC. |
| 2004-2006 |
Associate Professor (tenured), School of Public Health, Epidemiology, Prevention, and Control program leader, Stanley S. Scott Cancer Center; Endowed Wendell Gauthier Chair, Louisiana State University Health Sciences Center, New Orleans, LA. |
| 2006-Pres. |
Professor, Departments of Epidemiology and Public Health and Biochemistry, Associate Director for Prevention and Control, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL. |
Research Interests
Molecular and genetic epidemiology studies of DNA-repair genotypes and phenotypes in human cancer risk, progression, treatment outcome and prevention.
Selected Publications
Lea MA, Grasso SV, Hu JJ, and Seidler N. (1984) Factors affecting the assay of histone H1 and polylysine by binding of Coomassie blue G. Anal Biochem 141:390-396.
Lea MA, Hu JJ, and Grasso S. (1985) Disparity in the effects of two N-methylnicotinamides on poly(ADP-ribose) synthetase and macromolecular synthesis in hepatomas. Cancer Biochem Biophys 8:1-7.
Lea MA, Luke A, Hu JJ, and Velazquez O. (1987) Action of carbamoylating agents on the uptake of metabolites in hepatomas and liver. Biochem Pharmacol 39:2775-2781.
Hu JJ, Luke A, Chellani M, Zirvi KA and Lea MA. (1988) pH-Related effects of sodium cyanate on macromolecular synthesis and tumor cell division. Biochem Pharmacol 37:2259-2266.
Hu JJ, Dimaira MJ, Zirvi KA, Dikdan G and Lea MA. (1989) Influence of pH on the modification of thiols by carbamoylating agents and effects on glutathione levels in normal and neoplastic cells. Cancer Chemother Pharmacol 24:95-101.
Hu JJ, Zirvi KA and Lea MA. (1989) Interrelationship between sodium cyanate and pH in the regulation of tumor cell division. Cancer Biochem Biophys 10:269-274.
Hu JJ, Zirvi KA and Lea MA. (1990) Combined effect of pH and sodium cyanate on the inhibition of tumor cell proliferation and metabolism by BCNU and hyperthermia. Cancer Chemother Pharmacol 26:269-272.
Hu JJ, Rhoten RB and Yang CS. (1990) Mouse renal cytochrome P450IIE1: Immunocytochemical localization, sex-related difference and regulation by testosterone. Biochem Pharmacol 40:2597-2602.
Hu JJ, Lee M-J, Vapiwala M, Reuhl K, Thomas PE and Yang CS. (1993) Sex-related differences in mouse renal metabolism and toxicity of acetaminophen. Toxicol Appl Pharmacol 122:16-26.
Hu JJ, Dubin N, Kurland D, Ma B and -*Roush GC. (1995) The effects of hydrogen peroxide on DNA repair activities. Mut Res 336:193-201.
Hu JJ, Berwick M, Dubin N, Mahabir S, Chandiramani M and Roush GC. (1996) Dietary supplementation of α-tocopherol increases plasma glutathione and DNA repair. Cancer Epi Biomarker & Prev 5: 263-270.
Hu JJ, Yoo JH, Lin M, Wang EJ and Yang CS. (1996) Protective effects of diallyl sulfide on acetaminophen-induced toxicities. Food & Chem Toxic 34:963-969.
Hu JJ, Dubin N, Berwick M, Miesner J, Roses DF, Harris MN and Roush GC. (1997) Poly(ADP-ribose) polymerase in human breast cancer: a case-control analysis. Pharmacogenetics 7:309-316.
Hu JJ, Hong J-Y, Lea MA and Yang CS. (1998) Differential expression of cytochrome P4502E1 (CYP2E1) in Morris hepatomas and livers of tumor bearing rats. Int J Oncol 12:1049-1053.
Hu JJ, Chi CX, Frenkel K, Smith B, Hanfelt J, Berwick M, Mahabir S, and D’Agostino RB (1999) α-Tocopherol dietary supplement decreases titers of antibody against 5-hydroxymethyl-2'-deoxyuridine (HMdU). Cancer Epi Biomarker & Prev 8:693-698.
Hu JJ, Smith TR, Miller MS, Mohrenweiser HW, Golden A, and Case LD. (2001) Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity. Carcinogenesis 22:917-922.
Hu JJ, Smith TR, Miller MS, Lohman K, and Case LD. (2002) Genetic regulation of ionizing radiation sensitivity and breast cancer risk. Environ Mol Mutagen 39:208-215.
Xu J, Zheng SL, Komiya A, Mychaleckyj JC, Isaacs SD, Hu JJ, Sterling D, Lange EM, Hawkins GA, Turner A, Ewing CM, Faith DA, Johnson JR, Suzuki H, Bujnovszky P, Wiley KE, DeMarzo AM, Bova GS, Chang B, Hall MC, McCullough DL, Partin AW, Kassabian VS, Carpten JD, Bailey-Wilson JE, Trent JM, Ohar J, Bleecker ER, Walsh PC, Isaacs WB, Meyers DA. (2002) Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. Nat Genet 32:321-325.
Hu JJ, Mohrenweiser HW, Bell DA, Leadon SA, and Miller MS. (2002) Symposium overview: genetic polymorphisms in DNA repair and cancer risk. Toxicol Appl Pharmacol 185:64-73.
Smith TR, Miller MS, Lohman K, Lange EM, Case LD, Mohrenweiser HW, and Hu JJ. (2002) Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer. Cancer Lett 190:183-190.
Rao A, Chang B-L, Hawkins G, Hu JJ, Rosser CJ, Hall, MC, Meyers DA, Xu JF, Cramer SD. (2003) Analysis of the G/A polymorphism in the androgen response element I of the PSA gene and its interactions with androgen receptor polymorphisms. Urology 61:864-869.
Smith TR, Miller MS, Lohman K, Case LD, and Hu JJ. (2003) DNA damage and breast cancer risk. Carcinogenesis 24:883-889.
Liu TF, Tatter SB, Willingham MC, Yang M, Hu JJ, and Frankel AE. (2003) Growth factor receptor expression varies among high-grade gliomas and normal brain: epidermal growth factor receptor has excellent properties for interstitial fusion protein therapy. Mol Cancer Ther 2:783-787.
Smith TR, Levine EA, Perrier ND, Miller MS, Freimanis RI, Case LD, Lohman K, Mohrenweiser HW, and Hu JJ. (2003) DNA-Repair genetic polymorphisms and breast cancer risk. Cancer Epi, Biomarker & Prev 12:1200-1204.
Hu JJ, Hall MC, Grossman L, Hedayati M, Lohman K, and Case LD. (2004) Deficient DNA repair capacity enhances human prostate cancer risk. Cancer Res 64:1197-1201.
Lockett KL, Hall MC, Xu J, Zheng SL, Chuang SC, Clark PE, Cramer SD, Lohman K, and Hu JJ. (2004) The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function. Cancer Res 64:6344-6348.
Lockett KL, Snowhite IV, and Hu JJ. (2005) The genetic regulation of ADPRT/PARP-1 in aging and cancer susceptibility. Current Pharmacogenomics 3:9-19.
Lockett KL, Snowhite IV, and Hu JJ. (2005) Nucleotide-excision repair and prostate cancer risk. Cancer Lett 220:125-135.
Lockett KL, Hall MC, Clark PE, Lohman K, Chuang SC, Robinson B, and Hu JJ. (2006) DNA damage levels in prostate cancer cases and controls. Carcinogenesis 6: 1187-93.
Huang K, Sandler RS, Millikan RC, Olshan AF, Schroeder JC, North KE, and Hu JJ. (2006) GSTM1 and GSTT1 polymorphisms, cigarette smoking, and colon cancer: a population-based case-control study in North Carolina. Cancer Causes Control 4: 385-94.
Clark PE, Hall MC, Borden LS Jr, Miller AA, Hu JJ, Lee WR, Stindt D, D'Agostino R Jr, Lovato J, Harmon M, and Torti FM. (2006) Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse of prostate cancer after definitive local therapy. Urology 67:1257-61.
Van Emburgh BO, Hu JJ, Levine EA, Mosley LJ, Case LD, Lin HY, N. Knight SN, Perrier ND, Rubin P, Sherrill GB, Shaw CS, Carey LA, Sawyer LR, Allen GO, Milikowski C, Willingham MC, and Miller MS. Polymorphisms in drug metabolism genes, smoking, and p53 mutations in breast cancer. Mol Carcinogenesis 2007 Aug 7; [Epub ahead of print].
Goodwin WJ, Thomas GR, Parker DF, Joseph D, Levis S, Franzmann E, Anello C, and Hu JJ. The unequal burden of head and neck cancer in the United States. Head & Neck (in press).
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