TRANSPLANTATION BIOLOGY / GRAFT VERSUS HOST DISEASE
Research
in transplantation biology seeks to understand the biological and immunological
hurdles in the transplantation of human tissue from one individual to
another. Graft rejection can be a problem when the recipient's immune
system sees the graft as foreign and launches an attack against it. In
Graft versus Host Disease (GvHD) the numerous T cells in grafts of bone
marrow see the tissues of the recipient as foreign antigen and mount an
immune attack against them. Research in this area seeks to overcome these
and other complications associated with tissue tranplant.
Robert Levy and Eckhard Podack - The application of genetically engineered and functionally deficient T cells in allogenic bone marrow transplantation
Laphalle Fuller and Violeta Esquenazi - Donor bone marrow and transplant T and B cell regulation; Regulator T and B cell circuits in transplantation; Immunoregulation in the biology of transplantation and autoimmune disease; Living related donor bone marrow immunoregulation in kidney transplants
Eckhard Podack and Robert Levy- Pathophysiology of perforin expression in autoimmunity and transplantation
Roland Jurecic - In utero stem cell transplantation; Developmental plasticity of hematopoietic and mesenchymal stem cells
