CURRICULUM
FIRST
YEAR REQUIRED GRADUATE COURSES
Fall
Semester IBS 601 Interdisciplinary Biomedical
Science - (5 credits)
Description: An interdisciplinary survey of molecular and cellular
biology, including topics in protein structure and function; protein
synthesis; nucleic acids and the genetic code; gene technology;
genetic analysis; control of cellular activity; molecular anatomy
of genes and chromosomes; DNA replication, repair, and recombination;
regulation of transcription; and RNA processing and posttranscriptional
control.
MIC 605 Faculty Research and Discussions - (1 credit)
Description: Forum for the discussion of the current research
projects and interests of the faculty. This course will provide
students with the opportunity to exchange ideas about important
scientific questions and the technologies being applied to experimentally
address the hypotheses being tested.
MIC 626 Laboratory Experimentation - (4 credits)
Description: Intensive and extensive laboratory experience in
the areas of microbiology, immunology, virology, and molecular
biology. The purpose of MIC 626 is to introduce students to laboratory
procedures, contemporary methodology, use of instrumentation,
experimental design and data analysis within the major disciplines
represented in the department. Students select three rotations,
each is approximately 12 weeks. Following each rotation, a brief
presentation will be given.
MIC 628 Graduate Immunology - (5 credits)
Description:
Examination of the cellular and molecular components of the immune
system, how its normal function eliminates microorganisms, and
how its abnormal function leads to human disease. Topics to be
addressed include: hematopoiesis, antigen-specific receptors,
the major histocompatibility complex, antigen-processing and presentation,
lymphocyte development and activation, regulation of the immune
response, effector mechanisms of immunity, innate immunity, immune
responses to infectious organisms, autoimmunity, tumor immunity,
and transplantation immunology. Students meet three hours per
week in lectures on these topics and two hours per week discussing
current and classic research papers in immunology.
MIC 680 Research Ethics - (0 credits)
Description: Principles of scientific integrity, responsible conduct
of research, and UM Honor Code. Students are required to take
this two session, non-credit course. This is a mandated course
required by the university and must be completed prior to graduation.
Spring
Semester
IBS 603 Interdisciplinary Biomedical Science - (4 credits)
Description: A continuation of IBS 601, this course has been split into four modules. Module 1, Cell Signaling: this module dissects at the molecular level how extracellular signals initiate intracellular signaling pathways. Module 2, Cell Membrane and Physiology: this module dissects at the molecular level the biophysics of cell membranes and channels. Module 3, Principles of Development and Immunology: this module dissects mammalian development at the molecular level and introduces the developmentally controlled mechanisms of the immune system that generates immune specificity and diversity. Module 4, Molecular Aspects of Human Disease: this module applies interdisciplinary concepts of the life sciences to discuss the cause and therapy of human disease. Each module is 1 credit and students are to take all 4 modules in the Microbiology and Immunology Program.
MIC 523 Mechanisms of Microbial Virulence – (5 credits)
Description: This course primarily focuses on mechanisms employed by bacterial and viral pathogens to produce disease in animals, plants and humans. The course explores both the basic biology of pathogenic bacteria and viruses, as well as specific mechanisms of virulence. The general topics that will be addressed include: identification of virulence factors, virulence gene regulation, invasion of eukaryotic cells, delivery of bacterial virulence factors, bacterial toxins, and viral replication. Classes will consist of a mixture of lectures and discussions of recent or classic papers. Prerequisites: IBS 601
MIC 627 Laboratory Experimentation - (6 credits)
Description: Intensive and extensive laboratory experience in
the areas of microbiology, immunology, virology, and molecular
biology. The purpose of MIC 627 is to introduce students to laboratory
procedures, contemporary methodology, use of instrumentation,
experimental design and data analysis within the major disciplines
represented in the department. Students select three rotations,
each is approximately 12 weeks. Following each rotation, a brief
presentation will be given.
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ELECTIVE
(ADVANCED) GRADUATE COURSES:
MIC 611 Accelerated Basic Science Medical Curriculum - (18 credits)
Description: Transfer for graduate credit of basic science medical
course work for individuals enrolled in combined degree (i.e.
M.D./Ph.D.) programs.
MIC 631 Special Projects - (1-5 credits)
Description: Special work, lecture, laboratory, or a combination
as determined by the advisor in accord with student's individual
interest. Prerequisite: Permission of advisor and the graduate
program director. Offered on demand.
MIC 651 Advanced Topics in Immunology - (3 credits)
Description: Each year, selected topics in immunobiology will
be discussed addressing the contemporary issues and questions
regarding development, regulation, and function in the immune
system. This year’s course is entitled, “Lymphocyte
Differentiation.” Please contact the Graduate Program Office
at 305-243-5682 for information concerning the annual topic. Prerequisite:
MIC 628.
MIC 655 - Infectious Agents and the Immune System (3 credits)
Description: This course is intended to explore, at an advanced level, the dynamic equilibrium that exists between microbial pathogens and host immune systems with emphasis on factors that influence progression to disease or sterilizing immunity. Mechanisms employed by the host and pathogen to shift that equilibrium in their favor will be discussed taking into account interactions at the cell systems, cellular, and sub-cellular levels. To facilitate interaction between the two fields, both and immunological and a microbial/virology faculty member will be present at all classes. Prerequisite: MIC 523 or permission of instructor.
MIC 661 Retroviruses and Viral Oncology* - (2 credits)
Description: The nature of retroviruses, cellular regulation of
viral genes, pathogenesis of viral infections, and mechanisms
of retroviral oncogenesis. Lectures and discussions of assigned
readings. Prerequisite: MIC 523. *This course is only offered
in even numbered years.
MIC 699 Advanced Topics - (1 credit)
Description: Contemporary subject matter offerings based upon
expertise of faculty. Subtitles describing the topics to be offered
will be shown in parentheses in the printed class schedule, following
the title "Advanced Topics." Mini-courses to be offered
will be announced prior to each semester. Contact the Graduate
Program Office at 305-243-5682 for additional information.
BMB 614 Molecular Genetics (3 credits)
Description: This course deals with mechanisms of inheritance
with particular emphasis on fundamental genetic processes in bacteria,
bacteriophage, fungi, and animal viruses. Topics will include:
the nature of mutations and mechanisms of mutagenesis; genetic
complementation, recombination and transposition; transcriptional
and post-transcriptional regulation; yeast and other fungi as
tools of eukaryotic molecular biology, human genetic analysis,
and genetic mechanisms in bacterial and mammalian viruses.
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DISSERTATION
RESEARCH CREDITS
MIC 730 Doctoral Dissertation - 1-12 credits (All Semesters)
Description: Required of all candidates for the Ph.D. The student
will enroll for credits as determined by the graduate office but
not for less than a total of 24. Not more than 12 hours of MIC
730 may be taken in a regular semester, nor more than six in the
summer. If a student has a) passed qualifying exam(s) and b) is
engaged in an assistantship, he/she may still take the maximum
allowable credits.
MIC 750 Research in Residence - 0 credit (All Semesters)
Description: Used to establish research for the Ph.D. after the
student has been enrolled for the permissible cumulative total
in appropriate doctoral research. May be regarded as full-time
residence as determined by the Dean of Graduate School.
To fulfill the 36 course credit hour requirements for the Ph.D.
degree, students may elect to take any other courses offered by
this department, or graduate level courses in other departments
at the medical school with appropriate approval.
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