Neuroscience 631 Special Topics in Neuroscience (Fall 2005) - 1 credit

Cell Adhesion Molecules in Axon Guidance
Course Instructor: Dr. Vance Lemmon

Description:
This course will review classic papers and concepts about cell adhesion molecules (CAMs) as well as recent advances in understanding how CAMs influence axon growth and guidance in development and regeneration. While we will focus on classic CAMs, such as N-cadherin, N-CAM, L1 and integrins, we will also examine ephrins and other signals, such as slit. The basic approach will be a short review by the instructor followed by in depth discussion of papers presented by students. Typically 4 papers will be discussed each week.

Week 1) The discovery of CAMs; classic assays and methods
Week 2) CAMs and cell migration, affinity and avidity
Week 3) CAM based axon guidance in flies
Week 4) CAM based axon guidance in vertebrates
Week 5) Ephrins and the visual system
Week 6) RPTPs, Slit, Comm, Robo

Time:
The sessions will be in the early evening on the following Wednesdays:
Sept 7, 14, 21 and Oct 5, 12, 19

For More Information:
Please call Samone Welch or Sean Rinehart in the Neuroscience Program Office for further details 305.243.3368 or email neurosci@med.miami.edu.

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